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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Gastrointestinal disease

oral cavity neoplasm

A neoplasm (disease) that involves the oral cavity.

๐Ÿ”” Follow weekly
๐Ÿงฌ6209genes / proteins with evidence
๐Ÿ’Š22drugs and clinical candidates
๐Ÿงช12+recruiting trials worldwide
โœ…3phase 3
๐Ÿ“ˆ2phase 2/3
๐Ÿงฌ

Understand oral cavity neoplasm

Cancer ยท Cells that grow out of control
๐ŸŽ“ Learn more

What it is

Oral cancer is cancer of the mouth. It is a type of head and neck cancer. Most oral cancers are squamous cell cancers. They begin in the flat cells that cover the surfaces of your mouth, tongue, and lips. The cancer cells may spread into deeper tissue as the cancer grows.

Most oral cancers are related to tobacco use, heavy alcohol use, or an HPV infection.

Who is more likely to develop oral cancer?

From MedlinePlus: Oral Cancer (US National Library of Medicine) โ†—

๐Ÿงฌ Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

โ“ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

๐Ÿซ€ What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

๐Ÿงฑ Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

๐Ÿš€ What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for oral cavity neoplasm itself.

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AI briefing

Where the science on oral cavity neoplasm stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens oral cavity neoplasm.

๐ŸŽฏ

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
TP53 tumor protein p53PROTACothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.67
NOTCH1 notch receptor 1PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.63
CDKN2A cyclin dependent kinase inhibitor 2A๐ŸงŠ AlphaFold structure โ†— 0.63
HRAS HRas proto-oncogene, GTPasePROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.61
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.61
FAT1 FAT atypical cadherin 1PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.57
MAML2 mastermind like transcriptional coactivator 2๐ŸงŠ AlphaFold structure โ†— 0.56
CRTC1 CREB regulated transcription coactivator 1PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.56
NFIB nuclear factor I BPROTAC๐ŸงŠ AlphaFold structure โ†— 0.55
MYB MYB proto-oncogene, transcription factorPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.54
KMT2C lysine methyltransferase 2CPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.54
FBXW7 F-box and WD repeat domain containing 7PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.54
CRTC3 CREB regulated transcription coactivator 3PROTAC๐ŸงŠ AlphaFold structure โ†— 0.53
CASP8 caspase 8PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.53
HMGA2 high mobility group AT-hook 2PROTAC๐ŸงŠ AlphaFold structure โ†— 0.53

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

๐Ÿ’Š

Drugs and candidates

Every medicine linked to oral cavity neoplasm, by how far it has got
In phase 2 / 3 ยท 10
CisplatinPhase 3
Contusugene LadenovecCellular tumor antigen p53 exogenous genePhase 3
FluorouracilThymidylate synthase inhibitorPhase 3
AspirinCyclooxygenase inhibitorPhase 2/3
CetuximabEpidermal growth factor receptor erbB1 inhibitorPhase 2/3
Aminolevulinic AcidPhase 2
Show all 10
CarboplatinPhase 2
HydroxyureaRibonucleoside-diphosphate reductase RR1 inhibitorPhase 2
MetronidazolePhase 2
PaclitaxelTubulin inhibitorPhase 2
Early trials ยท 6
CalcitriolVitamin D receptor agonistPhase 1/2
CelecoxibCyclooxygenase-2 inhibitorPhase 1/2
EniluracilDihydropyrimidine dehydrogenase inhibitorPhase 1/2
FluconazoleCytochrome P450 51 inhibitorPhase 1
MogamulizumabC-C chemokine receptor type 4 cross-linking agentPhase 1
NivolumabProgrammed cell death protein 1 inhibitorPhase 1
๐Ÿงช

Recruiting trials

Worldwide, open to new patients now
Tirelizumab in Combination With Carboplatin and Albumin-binding Paclitaxel for Neoadjuvant Therapy in HNSCCNCT05941338 ยท Phase 2 ยท ๐Ÿ“ GuangzhouVMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors orโ€ฆNCT03556228 ยท Phase 1, Phase 2 ยท ๐Ÿ“ Santa RosaPrevalence and Clinical Implications of HPV Infection in Male IBD PatientsNCT05911750 ยท n/a ยท ๐Ÿ“ BarcelonaDrug Screening Using Novel IMD in Salivary and Head and Neck CancersNCT05553782 ยท EARLY Phase 1 ยท ๐Ÿ“ BostonWindow Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck CancerNCT06819228 ยท Phase 1 ยท ๐Ÿ“ NashvilleDocetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma,โ€ฆNCT07667400 ยท Phase 1, Phase 2 ยท ๐Ÿ“ BethesdaPrediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based ImmunoscoreNCT03975322 ยท n/a ยท ๐Ÿ“ ErlangenProsthesis Guided Speech Rehabilitation of T1/T2 Cancers of the TongueNCT02584270 ยท NA ยท ๐Ÿ“ Ann ArborA Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab MonotherapyNCT06362369 ยท Phase 1, Phase 2 ยท ๐Ÿ“ AuroraTES RCT Fleet Enema vs Oral Mechanical Bowel PrepNCT05148494 ยท Phase 4 ยท ๐Ÿ“ HalifaxStudy of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary MetastasesNCT03093909 ยท Phase 1 ยท ๐Ÿ“ HoustonDual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and OropharynxNCT07343271 ยท n/a ยท ๐Ÿ“ Strasbourg Search more trials โ†’
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy