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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

๐ŸŽฏ Match trials to me

30 recruiting trials

for Advanced Unresectable

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) NCT06780111Phase 1, Phase 252 sites๐Ÿ“ Pittsburgh๐Ÿ“ Natal๐Ÿ“ Porto Alegre Merck Sharp & Dohme LLC ยท Tests: Pembrolizumab, I-DXd, Leucovorin, Levoleucovorin, 5-Fluorouracil (5-FU) A Clinical Trial Evaluating TQB2102 for Injection in Combination With Behmosubaisumab/Payamprolizumab With or Without Chemotherapy in Unresectable Locally Advanced, Recurrent, or Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastroesophageal Adenocarcinoma NCT06767800Phase 239 sites๐Ÿ“ Fuyang๐Ÿ“ Lu'an๐Ÿ“ Maanshan Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharโ€ฆ ยท Tests: TQB2102 for injection (7.5 mg) +Benmelstobart+Chemotherapy, TQB2102 for injection (6 mg/7.5 mg) +Benmelstobart+Chemotheโ€ฆ Testing Atezolizumab With Selinexor in People โ‰ฅ 12 Years Old With Alveolar Soft Part Sarcoma, AXIOM Trial NCT05333458Phase 213 sites๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles National Cancer Institute (NCI) ยท Tests: Atezolizumab, Biopsy Procedure, Biospecimen Collection, Computed Tomography, Echocardiography Test A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement NCT07359820Phase 219 sites๐Ÿ“ Phoenix๐Ÿ“ Jacksonville๐Ÿ“ Tampa Elevar Therapeutics ยท Tests: Lirafugratinib Brachytherapy (Iodine-125 Seeds) and Fluzoparib Combination Therapy for Advanced Unresectable Soft Tissue Sarcoma NCT05894018Phase 21 site๐Ÿ“ Guangzhou Fujun Zhang ยท Tests: Fluzoparib, Radioactive particle implantation A Phase II Study of GFH375 Combined With GFS202A or GFH276 Versus GFH375 in Patients With Previously Treated Locally Advanced Unresectable or Metastatic Pancreatic Cancer Harboring KRAS G12D Mutation NCT07784374Phase 21 site๐Ÿ“ Shanghai Genfleet Therapeutics (Shanghai) Inc. ยท Tests: GFH375, GFH276, GFS202A Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology NCT05756569Phase 24 sites๐Ÿ“ Atlanta๐Ÿ“ Atlanta๐Ÿ“ Atlanta Emory University ยท Tests: Biospecimen Collection, Computed Tomography, Enfortumab Vedotin, Magnetic Resonance Imaging, Pembrolizumab Conversion Therapy With RC48, Sintilimab, and SOX for HER2 1+/2+ Unresectable Gastric Cancer NCT07194005Phase 21 site๐Ÿ“ Shanghai Fudan University ยท Tests: Disitamab vedotin(RC48), Sintilimab, S-1, Oxaliplatin Nimotuzumab Plus Definite Chemoradiotherapy(dCRT) in Elderly Patients With Esophageal Squamous Cell Carcinoma NCT06988956Phase 21 site๐Ÿ“ Nanjing The First Affiliated Hospital with Nanjing Medical Universiโ€ฆ ยท Tests: Nimotuzumab, Tegafur, radiotherapy Ablative Carbon Ion Radiotherapy With Pencil Beam Scanning for Locally Advanced Unresectable Pancreatic Cancer NCT05424159NA1 site๐Ÿ“ Shanghai Shanghai Proton and Heavy Ion Center ยท Tests: Carbon ion radiotherapy A Study to Observe the Safety of VYLOY (Zolbetuximab) in People in South Korea With Gastric or Gastroesophageal Junction Cancer. NCT06902545n/a15 sites๐Ÿ“ Goyang-si๐Ÿ“ Suwon๐Ÿ“ Suwon Astellas Pharma Korea, Inc. ยท Tests: zolbetuximab RGL-270 + ICI in Advanced NSCLC NCT07652125NA1 site๐Ÿ“ Guangzhou Guangdong Association of Clinical Trials ยท Tests: RGL-270 in Combination with PD-1/PD-L1 Inhibitors, Physician's Choice SOC The COMPASSION Study NCT06507930NA1 site๐Ÿ“ Boston Dana-Farber Cancer Institute ยท Tests: Telehealth Hospice Visits A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma NCT07043400Phase 395 sites๐Ÿ“ Chandler๐Ÿ“ Los Alamitos๐Ÿ“ Colorado Springs BeOne Medicines ยท Tests: Subcutaneous Tislelizumab, Intravenous Tislelizumab, Cisplatin, Leucovorin, 5-fluorouracil (5-FU) A Dose-Expansion Trial of Intravenous HNF4ฮฑ srRNA for Unresectable or Metastatic Colorectal Cancer NCT07050394EARLY Phase 11 site๐Ÿ“ Shanghai Shanghai Changzheng Hospital ยท Tests: CD-GA-102 AK112 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/ Metastatic Triple-negative Breast Cancer NCT06767527Phase 31 site๐Ÿ“ Beijing Akeso ยท Tests: AK112, Nab-paclitaxel, Placebo First-line Treatment With RC48 Plus Sintilimab and S-1 in Advanced Gastric Cancer (RCTS2) NCT06730373Phase 220 sites๐Ÿ“ Zhengzhou๐Ÿ“ Binzhou๐Ÿ“ Dongying Qilu Hospital of Shandong University ยท Tests: Disitamab Vedotin, Sintilimab, S-1, Trastuzumab, Oxaliplatin Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer NCT06958328Phase 3333 sites๐Ÿ“ Gilbert๐Ÿ“ Gilbert๐Ÿ“ Peoria NRG Oncology ยท Tests: Biopsy Procedure, Biospecimen Collection, Capecitabine, Computed Tomography, Dose-escalated Radiation Therapy Induction Chemo-Immunotherapy + Radiotherapy vs Concurrent Chemoradiotherapy for Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma NCT07559045Phase 21 site๐Ÿ“ Zunyi Second Affiliated Hospital of Zunyi Medical University ยท Tests: Paclitaxel plus Cisplatin or Carboplatin (Induction Chemotherapy), Weekly Paclitaxel plus Cisplatin or Carboplatin (Conโ€ฆ A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors NCT06440005Phase 17 sites๐Ÿ“ Los Angeles๐Ÿ“ Sarasota๐Ÿ“ St Louis Angiex, Inc. ยท Tests: AGX101 Atezolizumab and Bevacizumab Plus TACE-HAIC for Unresectable Advanced HCC: a Phase 2 Clinical Trial NCT05751343Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: TACE-HACI, plus atezolizumab-bevacizumab Hypofractionated vs. Conventional Chemoradiotherapy After Induction Chemo-immunotherapy for Unresectable Esophageal Squamous Cell Carcinoma NCT06912074Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Induction chemoimmunotherapy, Hypofractionated Radiation Therapy, Conventional Fractionated Radiation Therapy, Concurreโ€ฆ Pembrolizumab Maintenance After Enfortumab Vedotin (EV)/Pembro Induction in Front-Line Metastatic Urothelial Carcinoma NCT07221942Phase 21 site๐Ÿ“ Philadelphia Fox Chase Cancer Center ยท Tests: Enfortumab vedotin, Pembrolizumab Mirdametinib in Patients With Advanced NF1-mutant Melanoma NCT07237100Phase 21 site๐Ÿ“ San Francisco Kevin Kim, MD ยท Tests: Mirdametinib XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma NCT06571734Phase 21 site๐Ÿ“ Chicago Northwestern University ยท Tests: Biospecimen Collection, Computed Tomography, Echocardiography, Multigated Acquisition Scan, Zanzalintinib A Study of BL-B16D1 in Patients With Unresectable Locally Advanced or Metastatic Breast Cancer and Other Solid Tumors NCT06493864Phase 11 site๐Ÿ“ Shanghai Sichuan Baili Pharmaceutical Co., Ltd. ยท Tests: BL-B16D1 Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors NCT06535607Phase 298 sites๐Ÿ“ Los Angeles๐Ÿ“ Baltimore๐Ÿ“ New York AstraZeneca ยท Tests: Volrustomig, Cisplatin, Carboplatin, Paclitaxel, 5-FU Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma NCT04598009Phase 22 sites๐Ÿ“ La Jolla๐Ÿ“ San Francisco University of California, San Francisco ยท Tests: Binimetinib, Imatinib A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC278 in the Treatment of Solid Tumors NCT07105215Phase 1, Phase 239 sites๐Ÿ“ Beijing๐Ÿ“ Fuzhou๐Ÿ“ Fuzhou RemeGen Co., Ltd. ยท Tests: RC278 Efficacy of Stereotactic Body Radiotherapy (SBRT) Combined With Maintenance Therapy Compared to Maintenance Therapy Alone in Advanced Pancreatic Cancer NCT07600268Phase 21 site๐Ÿ“ Jinan Shandong Cancer Hospital and Institute ยท Tests: Stereotactic Body Radiotherapy (SBRT) with maintenance therapy, Maintenance therapy
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